Publications in 2021

Combinatorial Histone H3 Modifications Are Dynamically Altered in Distinct Cell Cycle Phases

Combinatorial Histone H3 Modifications Are Dynamically Altered in Distinct Cell Cycle Phases. Lu C, Coradin M, Janssen KA, Sidoli S, Garcia BA. J Am Soc Mass Spectrom. 2021 Apr 5. doi: 10.1021/jasms.0c00451.

Structure of TFIIK for phosphorylation of CTD of RNA polymerase II

Structure of TFIIK for phosphorylation of CTD of RNA polymerase II. van Eeuwen T, Li T, Kim HJ, Gorbea Colón JJ, Parker MI, Dunbrack RL, Garcia BA, Tsai KL, Murakami K. Sci Adv. 2021 Apr 7;7(15):eabd4420.

Sex-specific effects of in vitro fertilization on adult metabolic outcomes and hepatic transcriptome and proteome in mouse

Sex-specific effects of in vitro fertilization on adult metabolic outcomes and hepatic transcriptome and proteome in mouse. Narapareddy L, Rhon-Calderon EA, Vrooman LA, Baeza J, Nguyen DK, Mesaros C, Lan Y, Garcia BA, Schultz RM, Bartolomei MS. FASEB J. 2021 Apr;35(4):e21523.

Improved SILAC Quantification with Data-Independent Acquisition to Investigate Bortezomib-Induced Protein Degradation

Improved SILAC Quantification with Data-Independent Acquisition to Investigate Bortezomib-Induced Protein Degradation. Pino LK, Baeza J, Lauman R, Schilling B, Garcia BA. J Proteome Res. 2021 Apr 2;20(4):1918-1927.

An Esrrb and Nanog Cell Fate Regulatory Module Controlled by Feed Forward Loop Interactions

An Esrrb and Nanog Cell Fate Regulatory Module Controlled by Feed Forward Loop Interactions. Sevilla A, Papatsenko D, Mazloom AR, Xu H, Vasileva A, Unwin RD, LeRoy G, Chen EY, Garrett-Bakelman FE, Lee DF, Trinite B, Webb RL, Wang Z, Su J, Gingold J, Melnick A, Garcia BA, Whetton AD, MacArthur BD, Ma’ayan A, Lemischka IR. Front Cell Dev Biol. 2021 Mar 19;9:630067.

Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons

Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons. Kronman H, Torres-Berrío A, Sidoli S, Issler O, Godino A, Ramakrishnan A, Mews P, Lardner CK, Parise EM, Walker DM, van der Zee YY, Browne CJ, Boyce BF, Neve R, Garcia BA, Shen L, Peña CJ, Nestler EJ. Nat Neurosci. 2021 Mar 15. doi: 10.1038/s41593-021-00814-8. Online ahead of print.

Chromatin dysregulation associated with NSD1 mutation in head and neck squamous cell carcinoma

Chromatin dysregulation associated with NSD1 mutation in head and neck squamous cell carcinoma. Farhangdoost N, Horth C, Hu B, Bareke E, Chen X, Li Y, Coradin M, Garcia BA, Lu C, Majewski J. Cell Rep. 2021 Feb 23;34(8):108769.

Histone Modifications in Papillomavirus Virion Minichromosomes

Histone Modifications in Papillomavirus Virion Minichromosomes. Porter SS, Liddle JC, Browne K, Pastrana DV, Garcia BA, Buck CB, Weitzman MD, McBride AA. mBio. 2021 Feb 16;12(1):e03274-20.

Cryo-EM structures of engineered active bc1-cbb3 type CIII2CIV super-complexes and electronic communication between the complexes

Cryo-EM structures of engineered active bc1-cbb3 type CIII2CIV super-complexes and electronic communication between the complexes. Steimle S, van Eeuwen T, Ozturk Y, Kim HJ, Braitbard M, Selamoglu N, Garcia BA, Schneidman-Duhovny D, Murakami K, Daldal F. Nat Commun. 2021 Feb 10;12(1):929.

Enhancing Open Modification Searches via a Combined Approach Facilitated by Ursgal

Enhancing Open Modification Searches via a Combined Approach Facilitated by Ursgal. Schulze S, Igiraneza AB, Kösters M, Leufken J, Leidel SA, Garcia BA, Fufezan C, Pohlschroder M. J Proteome Res. 2021 Apr 2;20(4):1986-1996.

HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies

HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies. Slaughter MJ, Shanle EK, Khan A, Chua KF, Hong T, Boxer LD, Allis CD, Josefowicz SZ, Garcia BA, Rothbart SB, Strahl BD, Davis IJ. Cell Rep. 2021 Jan 19;34(3):108638.

Comparative proteomics identifies Schlafen 5 (SLFN5) as a herpes simplex virus restriction factor that suppresses viral transcription

 

Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module

Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module.
Li YC, Chao TC, Kim HJ, Cholko T, Chen SF, Li G, Snyder L, Nakanishi K, Chang CE, Murakami K, Garcia BA, Boyer TG, Tsai KL. Sci Adv. 2021 Jan 15;7(3):eabd4484.