Publications in 2013

Identification and interrogation of combinatorial histone modifications

Karch KR, Denizio JE, Black BE, Garcia BA. Identification and interrogation of combinatorial histone modifications. Front Genet. 2013, 4:264.

Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signaling

Simeoni F, Tasselli L, Tanaka S, Villanova L, Hayashi M, Kubota K, Isono F, Garcia BA, Michishita-Kioi E, Chua KF. Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signaling. Sci Rep. 2013, 3:3085.

H3R42me2a is a histone modification with positive transcriptional effects

Casadio F, Lu X, Pollock SB, Leroy G, Garcia BA, Muir TW, Roeder RG, Allis CD. H3R42me2a is a histone modification with positive transcriptional effects. Proc Natl Acad Sci U S A. 2013, 110(37):14894-9.

Initial characterization of histone H3 serine 10 O-acetylation

Britton LM, Newhart A, Bhanu NV, Sridharan R, Gonzales-Cope M, Plath K, Janicki SM, Garcia BA. Initial characterization of histone H3 serine 10 O-acetylation. Epigenetics. 2013, 8(10):1101-13.

Proteomic Interrogation of Human Chromatin Protein States. A chapter in Emili, Greenblatt, Wodak: Systems Analysis of Chromatin-Related Protein Complexes in Cancer

Bhanu, N.V., Garcia, B.A. Proteomic Interrogation of Human Chromatin Protein States. A chapter in Emili, Greenblatt, Wodak: Systems Analysis of Chromatin-Related Protein Complexes in Cancer. Springer Science. 2013, 149.

H4K20 methylation regulates quiescence and chromatin compaction

Evertts AG, Manning AL, Wang X, Dyson NJ, Garcia BA, Coller HA. H4K20 methylation regulates quiescence and chromatin compaction. Mol Biol Cell. 2013, 24(19):3025-37

Proteomic characterization of novel histone post-translational modifications

Arnaudo AM, Garcia BA. Proteomic characterization of novel histone post-translational modifications. Epigenetics Chromatin. 2013, 6(1):24.

Combining genomic and proteomic approaches for epigenetics research

Han Y, Garcia BA. Combining genomic and proteomic approaches for epigenetics research. Epigenomics. 2013, 5(4):439-52.

A quantitative atlas of histone modification signatures from human cancer cells

Leroy G, Dimaggio PA, Chan EY, Zee BM, Blanco MA, Bryant B, Flaniken IZ, Liu S, Kang Y, Trojer P, Garcia BA. A quantitative atlas of histone modification signatures from human cancer cells. Epigenetics Chromatin. 2013, 6(1):20.

Dysregulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epithelial-to-mesenchymal transition in breast cancer cells

Stadler SC, Vincent CT, Fedorov VD, Patsialou A, Cherrington BD, Wakshlag JJ, Mohanan S, Zee BM, Zhang X, Garcia BA, Condeelis JS, Brown AM, Coonrod SA, Allis CD. Dysregulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epithelial-to-mesenchymal transition in breast cancer cells. Proc Natl Acad Sci U S A. 2013, 110(29):11851-6.

Large-scale global identification of protein lysine methylation in vivo

Cao, X.J., Arnaudo, A.M., Garcia, B.A. Large-scale global identification of protein lysine methylation in vivo. Epigenetics, 2013, 8(5):477-85.

Proteomic and genomic approaches reveal critical functions of the H3K9 methylation pathway and Heterochromatin Protein-1γ in reprogramming to pluripotency

Sridharan, R., Gonzales-Cope, M., Bonora, G., Chronis, C., McKee, R., Mishra, N., Garcia, B.A.*, Plath, K.* Proteomic and genomic approaches reveal critical functions of the H3K9 methylation pathway and Heterochromatin Protein-1γ in reprogramming to pluripotency. Nature Cell Biology, 2013, 15(7):872-82. *co-corresponding authors

Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma

Lewis PW, Müller MM, Koletsky MS, Cordero F, Lin S, Banaszynski LA, Garcia BA, Muir TW, Becher OJ, Allis CD. Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma. Science. 2013, 340(6134):857-61.

Quantitative dynamics of the link between cellular metabolism and histone acetylation

Evertts AG, Zee BM, Dimaggio PA, Gonzales-Cope M, Coller HA, Garcia BA. Quantitative dynamics of the link between cellular metabolism and histone acetylation. J Biol Chem. 2013, 288(17):12142-51.

MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency

Gaspar-Maia A, Qadeer ZA, Hasson D, Ratnakumar K, Adrian Leu N, Leroy G, Liu S, Costanzi C, Valle-Garcia D, Schaniel C, Lemischka I, Garcia B, Pehrson JR, Bernstein E. MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency. Nat Commun. 2013, 4:1565.

Comprehending dynamic protein methylation with mass spectrometry

Afjehi-Sadat L, Garcia BA. Comprehending dynamic protein methylation with mass spectrometry. Curr Opin Chem Biol. 2013, 17(1), 12-9.

SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal

Binda O, Sevilla A, Leroy G, Lemischka IR, Garcia BA, Richard S. SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal. Epigenetics. 2013, 8(2).

Chromatin proteins captured by ChIP-mass spectrometry are linked to dosage compensation in Drosophila

Wang CI, Alekseyenko AA, Leroy G, Elia AE, Gorchakov AA, Britton LM, Elledge SJ, Kharchenko PV, Garcia BA, Kuroda MI. Chromatin proteins captured by ChIP-mass spectrometry are linked to dosage compensation in Drosophila. Nat Struct Mol Biol. 2013, 20(2), 202-9.

Validation of protein acetylation by mass spectrometry

Zee BM, Garcia BA. Validation of protein acetylation by mass spectrometry. Methods Molecular Biology, 2013, 981:1-11.

Heavy methyl-SILAC labeling coupled with liquid chromatography and high-resolution mass spectrometry to study the dynamics of site-specific histone methylation

Cao, X.J., Zee, B.M., Garcia, B.A. Heavy methyl-SILAC labeling coupled with liquid chromatography and high-resolution mass spectrometry to study the dynamics of site-specific histone methylation. Methods Molecular Biology, 2013, 77, 299-313.