News – Garcia Lab

News in 2023

July 2023

Training for lab members. Joanna L. and Kirill attend the MS Summer School in Madison, WI, and Francesca attends the Skyline User course in Seattle, WA.

The lab welcomes two new postdocs to the group, Carolina Bras and Bibhuti Palai!

June 2023

The Garcia Lab returns from a successful ASMS Conference. Several members presented posters, and Ben, Joanna L. and Axe gave user meetings talks.

Congrats to Axe for winning the ASMS Postdoctoral Career Development Award.

Congrats to Francisca for winning a BMB Department Professional Devlopment Award

The lab welcomes our newest graduate student to the lab, Kirill Miachin, who will be working on his MD/PhD.

May 2023

Congrats to Tom for being selected as a BMB Department Research Seed grant winner.

March 2023

The Garcia Lab returns from a great US HUPO Conference where we had several poster and lightning talk presentations. Ben wins a best lightning talk award for his “histone rap”.

New tools for RNA sequencing and modification mapping are published in Analytical Chemistry.

January 2023

The Garcia lab welcomes Joanna G. (Joey) to the lab as our new Technician.

Joanna L. publishes a review on histone modification crosstalk in the Biochemical Journal.

News in 2022

December 2022

Ben is re-elected to the HUPO Governing Council as a Western region representative (https://hupo.org/Governance).

Peder’s research on understanding the role of microbe metabolism on histone acetylation and gene expression is published in Cell Reports!

November 2022

Axe is awarded a BMB Department Elson Fellowship for outstanding contributions in the areas of teaching, scholarship, collegiality and citizenship within the department.

Ben is a named a Highly Cited Researcher by Clarivate.

October 2022

Ben is named the Best Latinx Head and Chair award winner from Inaugural Vanderbilt Basic Sciences’ Hispanic and Latin Heritage Month.

July 2022

The lab says goodbye to postdoc Peder Lund who will start his own lab at the Case Western Reserve School of Medicine.

May 2022

Two publications from the lab to detail new MS approaches for RNA modification analysis are published in JASMS and Analytical Chemistry, respectively.

March 2022

The Garcia lab moves into their new lab space in the South Building.

News in 2021

September 2021

Congratulations to Khadija who successfully defended her thesis!

July 2021

The Garcia Lab has relocated to the Washington University School of Medicine in St. Louis!

The Garcia Lab welcomes Faith Robison as the new Mass Spectrometry Manager/Scientist. Faith previously worked at ThermoFisher Scientific as a Field Service Engineer and Supervisor.

The Garcia Lab welcomes Xingyu Liu as a new postdoc to the group. Xingyu earned her PhD at the Stowers Institute co-advised by Jerry Workman and Michael Washburn.

Ben has been elected as an Alternate Councilor for the ACS Division of Analytical Chemistry.

June 2021

Congratulations to Yekaterina who successfully defended her PhD thesis! Next up a postdoc at Abbvie, best of luck.

Congratulations to Lindsay, who will be moving onto a position at Talus Bio, a company she helped establish!

Congrats to Josue as he starts his next position at UPenn, as a Johnson Foundation Fellow (an independent position)!

May 2021

The Garcia Lab says goodbye to Joe, who will move onto the MD/PhD program at the University of Kansas School of Medicine, best of luck!

Julia has passed her prelim exam, congrats!!

Hung has finished his research for the semester, and will next move onto graduate school at the Washington University School of Medicine, good luck!

April 2021

Lindsay has been selected for a talk in the AC DC Rising Stars in Analytical Chemistry Seminar Series, congratulations!

Amber has successfully defended her PhD, congrats and will move on to a postdoc at CHOP, congrats!

The lab says farewell to Kevin and Stephanie, who are off to a postdoc at CHOP and new position at GSK, respectively.

Neha has been awarded an American Chemical Society (ACS) Division of Analytical Chemistry Graduate Fellowship, congrats!!

Congcong’s work describing the characterization of histone H3 combinatorial modifications during the cell cycle is published in JASMS.

Michael has been awarded an NIH NRSA Predoctoral Fellowship, great job!

March 2021

Lindsay’s study to develop a new SILAC-DIA-MS workflow is published in the Journal of Proteome Research, and also has been highlighted here.

February 2021

Mariana Lopes Lund joins us as a postdoctoral researcher, welcome back!

News in 2020

December 2020

Collaboration with the Bhoj lab (CHOP) on new discoveries of histone H3.3 mutations in unidentified neurodevelopmental disorders is published in Science Advances.

Kevin Janssen has successfully defended his thesis! Congrats! He will next be a postdoc at the Children’s Hospital of Philadelphia (CHOP).

Khadija has been selected to participate in the 2021 St. Jude National Graduate Student Symposium (NGSS), congrats!

The lab says goodbye to Congcong who will be going back to China for her next career move as an Assistant Professor at Nankai University, congrats!

Collaborations with the Skoultchi lab (Albert Einstein) and Eckenhoff Lab (UPenn) to understand how histone H1 controls chromatin compaction, and to characterize volatile anesthetic drug binding sites in the TREK1 K2P channel are published in Nature and Elife, respectively.

Mariel Coradin successfully defends her thesis! Congratulations and best of luck in your new postdoctoral position in Colorado!

The Garcia Lab welcomes Axe Xie to the lab as our newest postdoc!

November 2020

Congcong’s review on proteomic approaches for epigenetics research is published in MCP, congrats!

Collaborations with the Jabado lab on the K27M induced methylation changes in gliomas, and with the Bonasio lab to understand how TET2 regulates tRNA fragments are published in Cell Reports and NSMB, respectively.

Peder is selected for the ASMS Emerging Talent program, congrats!

October 2020

Ben is elected to the HUPO Executive Committee for a 2-year term as a Member-at-Large.

A manuscript with the Lewis lab (Univ. of Wisconsin) to study H3.3G34W oncohistone mechanisms that drive mesenchymal tumors is published in PNAS.

New publications with the Berger lab (UPenn) to understand the connection of SIRT1 with senescence/aging and to identify epigenetic changes that occur during Alzheimer’s Disease are published in Nature Chemical Biology and Nature Genetics, respectively.

September 2020

Ben has been awarded the Human Proteome Organization (HUPO) Discovery in Proteomic Sciences Award.

Collaborations with the Jabado lab (McGill Univ.) and the Van Eyk lab (Cedar Sinai) on the role of the oncohistone mutation G34W in giant cell bone tumors, and to identify protein methylation in a mouse model of nonalcoholic steatohepatitis (NASH) disease are published in Cancer Discovery and Journal of Proteome Research, respectively.

August 2020

Heejong has been awarded an NIH F31 Graduate Fellowship from the NIA, congrats!

Congratulations to Neha, who has been selected for a graduate fellowship slot on the NIH T32 Structural Biology and Molecular Biophysics training grant!

The Lab says goodbye to Jen as she starts the next chapter of her career at the University of Connecticut Proteomics Facility, congrats!

July 2020

Lindsay is awarded a postdoctoral fellowship slot on the Immunology of Normal and Neoplastic Lymphocytes NIH T32 training grant, congrats!!

A collaboration with the Josefowicz lab (Weill Cornell) on the role of histone H3.3 in stimulated macrophages is published in Nature, while Kevin’s collaboration with the Gregory lab (UPenn) to understand how m⁶A deposition induces loss of RNA secondary structure resulting in changes in mRNA stability for transcripts encoding abiotic stress response is published in Plant Direct.

Richard’s collaboration with the Weitzman lab (CHOP) on how Adenovirus induced ubquitination affects RNA-protein interactions is published in Nature Microbiology.

The lab says goodbye to Abby who will start graduate school at Memorial Sloan Kettering soon, best of luck!

A collaboration with the Dou lab (Univ. of Michigan) on the role of the acetyltransferase MOF during cellular quiescence is published in Cell Stem Cell.

June 2020

Ben is named a Fellow of the Royal Society of Chemistry (FRSC)

Ben participates in the ASBMB/MCP Virtual Proteomics session giving a talk on some epigenetics cancer research.

Our collaboration (Michael and Bhanu) with the Gorbunova lab (Univ. of Rochester) on the role of KDM2A ADP-ribosylation controlling H3K36 methylation levels during DNA damage is published in Aging.

Ben completes his term as Chair of the NIH Enabling Analytical and Imaging Technologies (EBIT) study section.

A fun ASMS Conference for the Garcia Lab with Lindsay, Yekaterina and Josue giving talks, and others with posters. Ben helped out with the NIH/NSF grant workshop and was the Mystery Guest during the ASMS Lunchtime Trivia, lol.

May 2020

Collaboration with the Taylor Lab (University of Toronto) to study epigenetic changes in ependymomas is published in Cell.

The lab goes 3 for 3, as Janice, Neha and Michael have passed their 2nd year prelim candidacy exams, congrats to all!!

Former graduate student Dylan Marchione has won the Saul Winegrad Award for Outstanding Dissertation, congratulations! His graduation profile can be seen here.

Ben is re-elected to the US Human Proteome Organization (HUPO) board of directors.

Collaborations with the Gill lab (Penn) and the Sarma lab (Wistar) to identify chimeric antigen receptor (CAR) T cell therapy for solid tumors, and to investigate how ATRX-RNA interactions regulate PRC2 localization have been published in Nature Biotechnology, and Nature Communications, respectively.

April 2020

Collaborations with the Martinez lab (UT Southwestern) to study Jumonji protein activity in the malaria parasite, and with the Wu lab (UPenn) to understand how bacteria influence the neonatal microbiome are published in ACS Infectious Diseases, and Nature Microbiology, respectively.

Janice has been awarded an NSF Graduate Fellowship, congrats!!

Julia Tasca has joined the Garcia Lab (joint with Roberto Bonasio), welcome to the group!

Lindsay has been selected to receive the ASMS Postdoctoral Career Development Award, congratulations!

Former graduate student Kelly Karch (Wysocki lab at Ohio State) also is awarded an ASMS Postdoctoral Career Development Award, congrats.

March 2020

Janice is named “Honorable Mention” in the Ford Foundation Fellowship competition, nice job!

Ben is highlighted in ASBMB Today.

Collaborations with the Stanger lab (UPenn) and Bale lab (Univ. of Maryland) to understand the role of H3K36me2 during cancer metastasis and how extracellular vesicle transmit epigenetic information are published in Cancer Discovery and Nature Communications, respectively.

Richard’s review article on RNA modifications has been accepted in the Molecular Omics Journal, congrats!

Janice has been awarded an ASMS graduate student stipend and Fontaine Society travel award to attend the 65th ASMS Conference later this year.

Khadija has been selected to participate in the 70th Lindau Nobel Laureate Meeting in Germany later this summer, congrats!

Collaborative work with the Noh lab (EMBL) on the role of H3.3K4 during ESC differentiation and the Daldal lab (UPenn) to understand copper homeostasis in the prokaryotic model organism Rhodobacter capsulatus are published in Nature Genetics and Metallomics, respectively.

February 2020

The Garcia Lab is on Twitter!

Yekaterina has been awarded an American Society for Mass Spectrometry Graduate Travel Award to attend the annual conference in Houston this summer, congrats!

Sam’s research work on building a computational framework for analysis of modified RNA MS/MS spectra is published in Nature Communications, congrats!

Ben was interviewed for the Real Science Real Life Podcast.

Yekaterina presented at the Women in STEM Symposium at Penn, and this was mentioned in Penn Today!

Mariel C and Mariel M publish their Middle Down proteomics workflow in the journal Methods, nice work!

January 2020

Many lab publications have come out. Our collaborations with the Lakdawala and Wojcik labs to understand intracellular transport of viral RNA and to create a new method for proteomics analysis of FFPE tissue are published in Nature Communications and the Journal of Proteome Research, respectively. Additionally, Kevin’s manuscript to describe a combined approach for Bottom up and Middle down analysis of histones is published in JASMS.

News in 2019

December 2019

A special issue in honor of Ben receiving the ASMS Biemann Medal is published in the Journal of the American Society for Mass Spectrometry, see here.

Khadija won 3rd place in the poster competition at the Fox Chase Cancer Center Epigenetics Symposium, congrats!

Mariel C and Amber were selected to attend the 2020 St. Jude National Graduate Student Symposium (NGSS), they are one of only 38 students selected from over 1500 invited to apply!

November 2019

Dylan defends his PhD thesis, becoming the 10th PhD graduate from the Garcia Lab, congratulations and best of luck at Agios!

Laura publishes her work on improved detection of proteoforms using deep proteomics analyses and custom RNA databases in Genome Research, congrats.

October 2019

Our new collaborative study with the Berger lab (UPenn) on how alcohol contributes to histone acetylation in the brain to influence alcohol-related associative learning is published in Nature.

New collaborative manuscripts describing development of a novel α2 adrenergic agonist photolabel with the Eckenhoff lab (UPenn), and cross-talk between histone H3K23 and H3K14 acetylation with the Kutateladze lab (University of Colorado) are published in ACS Chemical Neuroscience and Nature Communications, respectively.

Peder and Stephanie’s protocols for lysine methylation characterization by MS is published in Methods in Enzymology, congrats!

Ben, Abby, Bhanu, Mariel C and Dylan return from a great visit to St. Jude Children’s Hospital for our Chromatin Consortium collaboration meeting.

September 2019

The lab says goodbye to Zuo-Fei, good luck in Memphis!

Ben has been re-elected to the United States Human Proteome Organization (US-HUPO) Board of Directors for another 3-year term.

Simone’s manuscript describing a method to assess chromatin compaction by MS is published in Scientific Reports, congrats!

Our new postdoc Lindsay Pino has arrived, welcome to the Garcia Lab!

Super M has received an NIH NRSA F31 Predoctoral Fellowship, congrats!

Ben has received the Distinguished Lectureship Award from the New Jersey American Chemical Society Mass Spectrometry Discussion Group.

Kevin publishes his work on simultaneous detection and quantification of single and combinatorial histone PTMs using a novel chromatographic approach to perform Bottom Up and Middle Down experiments in a single run in JASMS, congrats!

Collaborations with the Allis lab on the connection between DNA methylation and histone H3K36 methylation, and with the Reinberg lab on understanding the automethylation activity of PRC2 are published in Nature and Genes & Development, respectively.

Ben has been re-elected to the Human Proteome Organization (HUPO) governing council (Western region representative) for another 3-year term.

The Garcia Lab welcomes 1st year BMB student Adriana Santiago-Ruiz to the lab for the fall rotation.

August 2019

Yekaterina has been awarded a Blavatnik Family Graduate Fellowship in Biomedical Research, congrats!

Mariel C, Bella and Zuo-Fei present posters at the UPenn Chemistry Biology Interface Symposium, where Mariel was awarded first place.

July 2019

The Garcia Lab welcomes Avi, Bella and Paige, our summer HS students to the lab.

Collaborations with the Wallace lab (CHOP) and Blau lab (Stanford) describing mitochondrial regulation of the epigenome, and the role of histone acetylation in muscle regeneration are published in PNAS and Cell Reports, respectively. Kevin and Peder led the Garcia Lab effort on these collaborations.

June 2019

The Garcia Lab comes back from a great ASMS Conference where we had talks from Josue, Mariel C, Zuo-Fei, and Amber. We also had posters from Yekaterina, Joe, Abby, Simone, Bhanu, Khadija, Dylan, Super M, Kevin and Stephanie. Additionally, Josue was awarded the postdoctoral Award, Mariel M. a graduate student travel award, and Abby an undergraduate student travel award.

The Garcia Lab welcomes new BMB graduate student members Michael Gilbert, Janice Reynaga and Neha Srikumar to the group!

Dylan and Anumita publish their research on more accurate biomarkers for malignant peripheral nerve sheath tumors and microfluidic approaches for single cell proteomics in Modern Pathology and Analytical Chemistry, respectively.

The Garcia Lab welcomes new BMB rotation student Julia Tasca to the lab for a summer rotation.

Super M was named a finalist for the HHMI Gilliam Fellowship, congrats.

May 2019

The lab’s new publication describing a new ultra-throughput analysis of histone modifications is published in Genome Research.

Amber wins a poster award at the Children’s Hospital of Philadelphia Research Institute Poster Day and Symposium, congrats!

The Garcia Lab welcomes new postdoc Libby Porter to the group!

Yekaterina receives a travel award from the Delaware Valley MS Discussion Group to attend the upcoming ASMS conference where she will be presenting a poster, congrats!

Collaborations with the Lewis lab (Univ. of Wisconsin) on an ‘oncohistone-mimic’, Stephen Mack (Baylor College of Medicine) on K27M oncohistone mechanisms in gliomas, and the Blobel lab (CHOP) on new regulators of fetal hemoglobin (HbF) production are published in Nature Communication, Cancer Cell, and Blood Advances, respectively.

Yekaterina has been selected as a finalist for the Blavatnik Family Graduate Fellowship.

April 2019

Khadija and Hee Jong have passed their 2nd year prelim examinations, congrats!

Peder and Yekaterina’s methods article on protein acetylation is published in Methods in Molecular Biology, and a collaboration with the Blobel lab (CHOP) on the role of histone acetylation during mitotic transcription is published in Cell Reports.

Khadija is awarded an NSF Graduate Fellowship, and Hee Jong is named Honorable Mention for the NSF Graduate Fellowship, congratulations to both!

Abby wins the Garcia Lab 9th Floor Ballers NCAA Bracket Tournament Challenge, correctly being the only one to select UVa as the Champion. Ben and Peder finished a respectable 2nd and 3rd. “Auburn Joe” is born, and Amber, please stick to surface proteins

The Garcia lab welcomes visiting graduate student Hilde von Gruning (University of Pretoria) to the group for a short research collaboration stay.

March 2019

Collaborations with the Morrisey lab (UPenn) to study transcriptional factors that regulate lung epithelial homeostasis and with the Allis lab (Rockefeller University) to determine the cellular target of menin inhibition in glioma are published in Gene & Development and PNAS, respectively.

John’s work on the epigenetic mechanisms in MPNST cancers is published in Cancer Research, congrats!

Yekaterina gave a talk, and our former summer HS student Bella presented a poster at the Pittcon Conference in Philadelphia, PA.

Collaborations with the Maze lab (Mt. Sinai) on a new histone modification sertonylation, and with the Jabado lab (McGill University) to further understand how the H3K27M mutation affects H3K27 methylation spreading are published in Nature and Nature Communications, respectively. Additionally, Bhanu’s work describing signaling cross-talk with a trans-histone code during myogenesis is published in the Journal of Biological Chemistry, congrats.

The Garcia Lab is the featured lab of the month on the Epigenetics Institute website, check out the video here, and the Garcia Lab blog post here.

The Garcia Lab will have 4 talks (Josue, Zuo-Fei, Amber and Mariel C), and 12 posters at the ASMS Conference later this year, watch out Atlanta!

The Garcia Lab returns from the US HUPO Conference in Rockville, MD. Mariel C., Peder and Richard gave short talks; Khadija, Zuo-Fei, Kasia and Congcong gave lightning talks; Yekaterina gave a Tips & Tricks talk and Ben gave an invited talk. We also had poster presentations from Josue, Yekaterina, Jen, Khadija, Joe, Kasia, Abby, Bhanu, Zuo-Fei, Congcong and Super M. Last but not least, Yekaterina also won first place in the graduate student poster competition!

Richard’s collaboration with the Bonasio and Davidovich labs to map RNA-protein binding sites on the EZH2 complex that influence its activity is published in Nat Struct Mol Biol.

Mariel C. has been selected to attend the Lindau Nobel Laureate meeting in Germany, congrats!

Sam successfully defends his PhD thesis, congratulations Dr. Wein!

The Garcia Lab says goodbye to Simone, who is off to start his independent faculty position at the Einstein College of Medicine, you’ll be missed, best of luck!

February 2019

Abby has been selected to receive an Undergraduate Student travel award from the American Society for Mass Spectrometry (ASMS) to attend the annual ASMS conference in June, congratulations!

Former graduate student Kelly Karch has received a President’s Postdoctoral Scholars Fellowship from the Ohio State University to join Vicki Wysocki’s lab for her postdoctoral studies, congrats!

Mariel C. has been awarded a Graduate Student travel award from the American Society for Mass Spectrometry (ASMS) to attend the annual ASMS conference in June, congrats!

Amber has been selected to receive an AACR-Margaret Foti Scholar-in-Training award from the American Association for Cancer Research, congrats!

A collaborative study with the Berger lab (UPenn) on the role of p300 in senescence is published in Molecular Cell.

Congcong’s multi-omics study to interrogate signaling pathway crosstalk and epigenetic mechanisms during the epithelial to mesenchymal transition in cancer is published in Epigenetics and Chromatin.

Peder has been awarded a travel award to attend the US-HUPO conference next month.

Simone publishes a methods article on understanding the role of acetyl-CoA metabolism and histone modifications.

Peder has received a Chrohn’s and Colitis Foundation Postdoctoral Fellowship, congratulations!

Josue is awarded an American Society for Mass Spectrometry Postdoctoral Career Development Award, congrats!

The Garcia Lab says goodbye to Anumita, who will be starting her new position at Merck, good luck!

January 2019

The Garcia Lab welcomes our new BMB rotation students Kollin Schultz and Michael Gilbert to the group.

Collaborative studies with the Zaret lab (UPenn) on the role of heterochromatin during lineage commitment, and with the Wellen lab (UPenn) on the role of acetyl-CoA metabolism in pancreatic cancer are published in Science, and Cancer Discovery, respectively.

News in 2018

December 2018

Hee Jong has has been awarded an NIH Chemistry-Biology Interface graduate training fellowship, well done!

A collaborative manuscript with the Pierce lab (UPenn) to understand epigenetic mechanisms behind transgenerational cocaine addiction and behavioral consequences is published in the European Journal of Neuroscience.

The Garcia Lab says goodbye to Ranran, who will be starting a new position at MD Anderson in Houston, best of luck!

The Garcia Lab had the annual Holiday Party with food, games and a gift exchange. Bhanu won the best “ugliest” sweater contest, although there were several top contenders.

Sam’s preprint of his nucleics acids search enginine computaitonal platform is picking up by the Proteomics News BlogSpot.

The Garcia Lab participates in the Chemistry-Biology Interface Symposium. Simone gave a talk, and several members gave posters including Joe who won second place for his poster presentation.

Dylan and John’s review on cancer epigenetics is published in Expert Review in Proteomics.

Stephanie is awarded a Michael S. Brown Penn-GSK Postdoctoral Fellowship, congrats!

November 2018

Ben returns from BGS graduate student recruiting at the ABRCMS conference in Indianapolis. Former Garcia Lab summer student Nia Harmon gave an excellent talk.

The Garcia Lab returns from the Department/BMB graduate program retreat at the Poconos Mountains. We had several poster presentations (Josue, Yekaterina, Sam, Kevin, Richard, Mariel C, Mariel M, Dylan and Laura). Mariel C won second place in the poster competition and Ben defended his “Student Outreach” award title.

Anumita, Geoff and Jen present at the annual Biomedical Postdoctoral Research Symposium on campus, nice work!

Collaborations with the Kashina lab (UPenn) on the human arginylome, and with the Berger lab on histone modifications changes in clinically abnormal sperm are published in Scientific Reports, and the Journal of Assisted Reproduction and Genetics, respectively.

The Garcia Lab says goodbye to Mariana Lopes, our visiting graduate student who will be going back to Brazil to finish her PhD studies.

Ben is named the John McCrea Dickson M.D. Presidential Professor.

October 2018

The Garcia Lab welcomes our two new Chemistry rotation students Alice Wei and Tongheng Chen to the lab.

The Garcia Lab welcomes our new postdoc Stephanie Miller Lehman to Philly.

Ben is interviewed by The Analytical Scientist, read here.

Kelly’s manuscript describing Top and Middle Down Hydrogen-Deuterium exchange MS approaches for probing nucleosomal conformation is published in Structure.

Ben participates in a Panel Discussion on the past, present and future of quantitative proteomics for the ProteomicsNOW MS Virtual Event (www.proteomicsnow.com) sponsored by Thermo Fisher Scientific and Wiley Publishing.

Our collaboration with the Greenberg Lab describing the effect of phosphorylation on TIP60 during DNA damage is published in Molecular and Cellular Biology.

The Garcia Lab returns from a great experience at the HUPO 2018 conference in Orlando, FL. We had multiple poster presentations from the lab (Kasia, Jen, Josue, John, Dylan, Kevin, Mariel M, Amber, Joe, Yekaterina, Bhanu, Peder and Geoff). Amber was also chosen as one of 8 Finalists for the PhD Poster Competition, where she gave a 3 min short talk on her work. Later she was selected as one of the 3 winners of the competition! Laura, Mariel and Ben gave talks, and Yekaterina won a travel award. Overall, it was a fantastic conference and fun time.

September 2018

Collaboration with the Locasale lab (Duke) to understand acetate production from glucose is published in Cell.

Congratulations to Simone, who has accepted an offer to start his own lab at the Albert Einstein College of Medicine!

Our collaborative work with the Strome lab (UC Santa Cruz) to understand epigenetic memory and transmission of histone H3K36 methylation is published in Genetics.

Mariel M has been awarded an NIH Diversity Supplement grant award from the National Cancer Institute, congrats!

The Garcia lab welcomes Janice Reynaga and Neha Srikumar (both BMB graduate students) to the lab for the fall rotation.

August 2018

Yekaterina has been selected receive a travel award to present her work at the 2018 HUPO World Congress next month, congrats.

Ben Garcia is named to the editorial board of Molecular Omics, read here.

The Garcia Lab has a fun time at the Department of Biochemistry and Biophysics picnic. Kevin, Laura, Simone, Bella, Alina and Ben even helped the department team (“RNAces”) beat the Physiology department in the big softball game 4-3 (Bella even knocked in the winning run!).

Amber has been named a finalist for the PhD Poster Competition at next month’s World HUPO Congress. She will give a short presentation and compete against 7 other finalists, read here. Good luck!

The Garcia Lab says goodbye to Dr. Kelly Karch, who will travel the world before moving onto a postdoc position.

The Garcia Lab also says goodbye to our summer undergrad and HS researchers: Emily, Maura, Bella, Ayushi and Nia. Thanks for all the hard work!

Collaborative papers with Gerd Blobel (CHOP) and Jenny Brodbelt (UT Austin) are published in Science and the Journal of Proteome Research, respectively.

July 2018

The Garcia Lab has their annual Summer Lab Party. It was a really good time, lots of food (histone salad and nucleosome cake) and sports activities. Congratulations to Kevin and Simone (“Kev-mone”) for overcoming their differences and coming together to win the Wii Boxing Tournament!

Mariel C presented a poster on her work at the first annual Office of Research and Diversity Training Research Symposium here on campus.

Amber’s NIH F31 NRSA Predoctoral Fellowship is funded by the National Cancer Institute, congratulations!

Excited to announce that John Wojcik has officially started as an Assistant Professor in the Department of Pathology and Laboratory Medicine here at the University of Pennsylvania School of Medicine. Congratulations John, and looking forward to big things in the future from your new lab!

Ben and Donita Brady (Cancer Biology) are interviewed to discuss the Presidential Professorship and diversity in science by UPenn’s Office of Inclusion and Diversity (OID). This interview was included in the OID Annual Report (Page 7) which can be read here.

Hendrik Weisser from STORM Therapeutics visits the Garcia Lab and gives a seminar on the latest in RNA modifications analysis for therapeutic use.

Khadija has been awarded an NIH Pharmacology T32 graduate training fellowship, congrats!

Ben has been featured on the American Chemical Society (ACS) Scholars Alumni Profile Series, read here.

June 2018

The Garcia Lab returns from a fun and very successful ASMS Conference, where Anumita, Congcong and Simone gave great talks; and Sam, Richard, Ranran, Minghui, Mariana and Zuo-Fei presented posters. Oh and Ben also received the Biemann Medal! Read the official UPenn press release here, and a Proteomics blogspot recap here.

Our previous MCP article “A novel quantitative mass spectrometry platform for determining protein O-GlcNAcylation dynamics,” has been selected to appear in a special virtual JBC issue of ASBMB journals focusing on “Omics of lipids, glycans and polar metabolites.”

The Garcia Lab welcomes our summer undergraduate students Maura Gibbs (Oberlin College), Nia Harmon (Florida State University) and Emily Pillet (Drexel University) to the group.

Graduate student Khadija Wilson joins the Garcia Lab, welcome aboard!

Amber’s collaboration with the Bonasio Lab to annotate ncRNAs in the ant brain is published in Cell Reports. Other collaborations with the Reinberg lab (NYU), Reilly lab and Janicki lab are also published in Molecular Cell, Science Translational Medicine and JBC.

May 2018

Zuo-Fei’s EpiProfile 2.0 manuscript is published in the Journal of Proteome Research, and our collaboration with the Eckenhoff lab to identify propofol binding sites on kinesin is published in JBC, congrats!

Yekaterina has been awarded an NIH Chemistry-Biology Interface graduate training fellowship, congrats!

The Garcia Lab hosts the First Annual BMB 500 racing competition for the BMB graduate program. Mariel M and Mariel C finished 8th and 4th, respectively. Nice job!

Lucy graduates from Penn, congrats! Next stop some traveling and then onto medical school.

Richard receives a travel award from the Delaware Valley MS Discussion Group to attend the upcoming ASMS conference where he will be presenting a poster, congrats!

Geoff has been awarded a Damon Runyon Postdoctoral Fellowship, congrats!

April 2018

Ben Garcia will receive the Biemann Medal at this year’s American Society for Mass Spectrometry Conference. Read more about it here.

Our second year students, Mariel M, Yekaterina and Richard all pass their 2nd year prelim examinations, congrats!

Alina Garcia works in the lab for “Bring your child to work day”.

Graduate student Heejong Kim joins the Garcia Lab (joint student with the Murakami lab), welcome!

Anumita gives a talk at GSK during the Michael Brown Postdoctoral Program Symposium.

Peder’s collaboration with the Wu lab (UPenn) to investigate aerobic and anaerobic mechanisms in the gut microbiome are published in PNAS. Additionally, Kasia’s collaboration with the Witze lab (UPenn) on Wnt signaling promotion of melanoma is published in Elife, and a collaboration with th4e Reinberg lab (NYU) on PRC2 activity is published in Molecular Cell.

March 2018

Abby is awarded the Joel Barrish Fellowship from the Penn Chemistry Department to support her summer research work, congrats!

The Garcia Lab attends the US HUPO Conference in Minneapolis. Peder, Josue, Laura and John gave talks, while Anumita and Kelly presented posters and lightning talks. Kevin also led an evening career workshop.

Ben Garcia is named the next chair of the NIH Enabling Bioanalytical and Imaging Technologies (EBIT) study section.

The Garcia Lab welcomes our newest members, QE-HF, QE-HFX and Altis to Philly!

Our collaboration with the Eckenhoff lab to identify anesthetic drug binding sites on the GABA receptor is published in the FASEB Journal. Johayra and Simone’s review paper on the connection between metabolism and epigenetics is published in Proteomics.

February 2018

Kelly becomes the first Garcia Lab UPenn student to defend her PhD thesis. Congrats Dr. Karch!

Mariel C’s collaboration with the Berger and Capell labs here at UPenn on MLL4 regulation of epithelial progenitor gene expression is published (http://genesdev.cshlp.org/content/early/2018/02/12/gad.306241.117.full.pdf+html), congrats!

January 2018

Laura Romano (PGG) joins us for the winter rotation, welcome!

Our collaboration with the Klein lab “Phosphoproteomics reveals that glycogen synthase kinase-3 phosphorylates multiple splicing factors and is associated with alternative splicing” has been selected as the representative ‘Genomics and proteomics’ article for the 2017 retrospective collection called “The year in JBC: 2017”. Read about it here.

The Garcia Lab says goodbye to Sara on her new industrial position, best of luck!

News in 2017

December 2017

Yekaterina wins 3rd Place in the poster competition at the Chemistry-Biology Interface Symposium, congrats!

Our collaboration with the Zaret lab (UPenn) taking a multi-omics approach to identify heterochromatin factors that impede activation of gene expression patterns necessary for cell fate specification is published in Molecular Cell.

Ben is named to the Advisory Committee in the Division of Biological Sciences for the National Science Foundation (NSF).

Ben gives a short research talk at the Eastern PA section of the Leukemia and Lymphoma Society.

November 2017

A multi-Penn lab collaborative effort linking TDP-43 to chromatin remodeling complexes important for induction of protective disease gene expression in amyotrophic lateral sclerosis and frontotemporal dementia is published in Current Biology.

Bernard Delanghe from Thermo (creator of the Proteome Discoverer software) visits the Garcia Lab and gives a workshop on the capabilities of the latest software version.

The Garcia Lab returns from the Department/BMB graduate group retreat in the Poconos Mountains. Joe, Simone, Kasia, Yekaterina, Dylan, Kevin, Abby, Laura, Zuo-Fei, Mariel C, Amber and Sam presented posters, and Kelly gave a great talk. Additionally, Mariel C won 2nd Place for her poster in the Biophysics category, congrats!

Congratulations to Qi, as her manuscript “Assessment of quantification precision of histone post-translational modifications by using an ion trap and down to 50,000 cells as starting material” is published in the Journal of Proteome Research.

Peder gives a talk at the Penn/CHOP Microbiome Program Symposium.

Amber’s manuscript “GiaPronto: a one-click graph visualization software for proteomics datasets” is accepted by Molecular and Cellular Proteomics, and is picked up by the Proteomics news blogspot, congrats! GiaPronto can be accessed here.

Visiting graduate student Mariana Lopes (Instituto Butantan, Brazil) joins the lab, welcome!

A collaboration with the Gorbunova lab (Univ. of Rochester) on the naked mole rat epigenome (implications for cancer resistance and longevity ) is published in Stem Cell Reports., while another collaborative study with the Sykes lab (Fox Chase Cancer Center) describing the role of the kinase PKCε in supporting cell survival and disease progression in acute myeloid leukemia is published in Clinical Cancer Research.

October 2017

The Garcia Lab has their first Halloween/Murder Mystery Party. It was a great time, as Yekaterina was murdered by Laura, who went on to blow up the entire planet. Simone won best costume, and Joe won best actor. Awards for best carved pumpkins went to Khadija/Audri/Amber for their angry pumpkin and Bhanu for her double helix DNA pumpkin.

Johayra’s studies on the connection between metabolism and histone acyl modifications is published in Nature Communications, congrats!

Ben and Mariel M return from the SACNAS Conference in Salt Lake City, UT, where Mariel presented a research poster, and Ben recruited future graduate students for BGS and the BMB Program.

Kelly’s research on histone ADP-ribosylation is published in Molecular BioSystems, congrats!

The Garcia Lab comes back from the Epigenetics Institute Retreat at Citizens Bank Park (home of the Philadelphia Phillies). Mariel C gave a talk, and Kasia, Simone, Peder and Laura presented posters.

The Garcia Lab welcomes new postdoc Geoff Dann to the group.

Collaborations with the Bonasio lab (UPenn) on methods to determine RNA-binding protein domains, with the Weitzman lab to identify proteomes on viral genomes, and with the Berger lab on the role of cytoplasmic chromatin in senescence are published in JoVE, Molecular and Cellular Proteomics, and Nature, respectively.

September 2017

Collaborations with the Klein lab (UPenn), Eckenhoff lab (UPenn) and Lazar lab (UPenn) focusing on the GSK-3 phosphoproteome, identification of drug-binding sites on the transient receptor potential ankyrin 1 ion channel, and the HDAC3 interactome are published in JBC, the Biophysical Journal and Nature Communications, respectively.

The Garcia Lab comes back from a GRAAM (Garcia-Roeder-Allis-Armstrong-Muir) meeting at Rockefeller University where John presented his latest research.

Laura and Kevin present their research progress at the department Friday Research Discussion.

The Garcia Lab wishes Yanping well in her new position at Johnson & Johnson.

The Garcia Lab welcomes a new Research Specialist Joseph Cesare to the Quantitative Proteomics Resource Core.

PGG graduate student Khadija Wilson joins the group for the Fall rotation, welcome!

August 2017

Yekaterina’s research on global non-histone acetylation dynamics is published in Scientific Reports! Collaboration with the Bonasio lab (UPenn) on role of the peptide corazonin on Ant caste identity is published in Cell, and another study in collaboration with the Kang lab (Princeton) describing Nidogen 1 as an inducer cancer metastasis is published in Genes & Development.

Very sad to hear about the recent tragic events in Charlottesville, VA, but a nice reminder on the impact this town has had on the proteomics field can be found here.

The Garcia Lab is excited to hear about the Cell and Molecular Biology graduate subprogram Genetics and Gene Regulation being renamed as the Genetics and Epigenetics Program!

July 2017

Collaborative work with the Zaret lab (UPenn) to identify biomarkers of pancreatic ductal adenocarcinoma is published in Science Translational Medicine. Also check out the CBS News piece on the research work here. Also, a collaboration with Ramalho-Santos lab (UCSF) on vitamin C induction of demethylation of histone H3 in ES cells is published in Epigenetics & Chromatin.

The Garcia Lab welcomes new graduate students Richard Lauman and Mariel Mendoza (joint with the Berger lab) to the group!

Simone’s work to make Middle Down MS for histone PTMs more quantitative by incorporating SILAC labeling is published in Epigenetics & Chromatin. Additionally, our collaborative work with the Moazed lab (Harvard Univ.) on heterochromatin formation is published in Nature.

June 2017

Congrats to our honorary lab member Jarrett Remsberg (Mitch Lazar’s lab) who defended his PhD thesis and will be off for a postdoc in Ben Cravatt’s lab at the Scripps Research Institute.

Our collaboration with the You lab (UPenn) on Brd4 phosphorylation in carcinoma is published in PNAS. Simone’s review on Middle Down MS for chromatin biology research is also published in Expert Reviews in Proteomics.

The Garcia Lab welcomes three high school students for summer research: Aaron Garcia, Ryan Liu and Ayushi Jain.

Research Specialist Sara Montanez and Postdoc Jen Liddle (joint with Matt Weitzman/CHOP) join the Garcia Lab, welcome!

The Garcia Lab comes back from a fun and successful American Society for Mass Spectrometry Conference. We had 13 posters and Peder, Laura, Kelly, Kevin and Simone gave great talks. Ben helped co-organize a workshop and then won the Indy 500, and Dylan was fired and then re-hired. All in all, it was a great time!

The Garcia Lab welcomes incoming BMB graduate students Mary Szurgot and Hee Jong Kim for summer rotations.

An article highlighting Penn’s Presidential Professors is published online.

May 2017

Kevin presents a poster on his RNA MS work at the RNA Biology & Cancer Symposium here at Penn.

Simone returns from representing the lab in collaborator meetings at the Broad Institute and at the Instituto Butantan in São Paulo, Brazil.

Ben participates in a virtual meeting to kickoff the International Partnership between Helmholtz Zentrum München (HMGU) in Munich and the Penn Epigenetics Institute.

The Garcia Lab says goodbye to Qi, who will take a year off before coming back to begin graduate school at Penn. Good luck and see you again soon!

Kevin has received a travel award from the Delaware Valley Mass Spectrometry Discussion Group to attend the American Society for Mass Spectrometry Conference next month, congrats!

Our collaborative work with the Wysocka lab (Stanford University) on MLL3/MLL4 H3K4me1 independent function is published in Molecular Cell, while a collaboration with the Martinez lab (UT Southwestern) on JumonjiC inhibitors as therapeutic treatments for non-small cell lung cancer is published in Cell Reports. Another collaboration with the Morrisey Lab (UPenn) examining how lncRNA transcription factor interactions regulate tissue development is published in Genes and Development.

April 2017

Visiting graduate student Minghui Chen (Shanghai Jiao Tong University) joins the lab, welcome!

Laura has passed her 2nd year prelim exam, congrats!

Edwin has defended his PhD thesis in Pharmacology. Congratulations Dr. Yoo!

Mariel’s review article on investigating proteolytic cleavage by mass spectrometry is published in Expert Review of Proteomics, nice work!

The Garcia Lab welcomes first-year BMB graduate student Richard Lauman to the group for a Spring rotation.

The Garcia Lab is awarded a PennCHOP Microbiome Program pilot grant to fund studies into the crosstalk between the gut microbiome and host epigenetic mechanisms. Big props to Peder, who did all the heavy lifting on the proposal. Congrats!

Yekaterina Kori has officially joined the lab for her graduate thesis work, welcome aboard!

The Garcia Lab welcomes our new Technical Director Hyoungjoo Lee and new postdoctoral researcher Josue Baeza (who has been awarded a Penn Academic Diversity Postdoctoral Fellowship) to the group.

Congratulations to Qi, who has accepted the offer to join the Biochemistry and Molecular Biophysics graduate program here at Penn for her PhD studies!

Collaborations with the Birkholtz lab to map the histone PTMs changes during the malaria parasite life cycle is published in Scientific Reports., while other collaborations to characterize epigenome alterations in melanoma, and to identify RNA-protein interactions critical for root hair cell development in Arabidopsis thaliana are published in Cell Reports and Developmental Cell, respectively.

March 20171

Shu’s research publication “Preferential Phosphorylation on Old Histones during Early Mitosis in Human Cells” was selected as a “Highlight of 2016″ for the Journal of Biological Chemistry!

The Garcia Lab attends the Epigenetics Institute party to celebrate the elevation of the program to Institute status at Penn. Congrats!

The Garcia Lab returns from the 13th annual US HUPO Conference. Dylan, Mariel, Amber, Simone, Yekaterina, Kasia, Peder and Kevin all gave lightning talks, Ranran gave a short talk, and Ben also gave a talk and led an evening workshop. We also had 10 poster presentations as well. Dylan and Yekaterina were awarded student travel awards to attend the conference, and Mariel won first place in the poster competition!

The Garcia Lab welcomes Abigail Lemmon our new undergraduate researcher to the group.

Our collaborative project with the Kutateladze lab (University of Colorado School of Medicine) on understanding recognition of histone crotonyl modifications by the monocytic leukemia zinc-finger protein-related factor (MORF) is published in Structure. Another collaboration with the Eckenhoff lab (Penn) on investigating the mechanisms of inhaled general anesthetics is published in ACS Chemical Biology.

Ben returns from representing the US HUPO organization at FASEB’s Capitol Hill Day, where he spoke to congress about the importance of continued funding of scientific research.

Garcia Lab has 19 presentations (13 poster and 6 oral) accepted for the American Society for Mass Spectrometry (ASMS) conference in Indianapolis in June.

February 2017

Incoming postdoc Josue Baeza has been awarded a Penn Academic Diversity Postdoctoral Fellowship, congrats!

Amber wins a poster award at the annual CHOP Research Poster Day competition. Congrats!

The Garcia Lab welcomes new postdoc Anumita Saha to the group.

Several lab papers are published. Kevin’s paper on epigenetics and systems biology is published in Methods in Enzymology, Simone’s collaborative work with the Hummon lab (Norte Dame) to identify drug induced histone PTM changes in a 3D-tumor model is published in Analytical Chemistry, and another paper with the Pierce lab to understand cocaine induced epigenome reprogramming is published in Molecular Psychiatry (also check out the Press Release). Lastly, Kasia’s manuscript on systems-wide cellular changes during herpes virus infection is published in Molecular and Cellular Proteomics, congrats to everyone!

January 2017

The Garcia Lab is excited to hear that our multi-lab grant “THUNDER: Tolerant Hosts Using Novel Drug-Enhanced Resilience” has been funded by DARPA.

The Garcia Lab had their annual holiday party. It was a great time with good food, and a fun interesting gift exchange.

Kevin and Dylan present their research work at the Neuroepigenetics Symposium here at Penn, nice job!

The Garcia Lab is thrilled to hear that the Penn Epigenetics Program has now been elevated to the Penn Epigenetics Institute!

Collaborative work with the Moghe lab (Rutgers University) describing histone modifications indicative of cell transitional states is published in Science Reports, while another collaborative study with the Jabado lab (McGill University) focused on understanding the role of histone H3K36M mutations in head and neck squamous cell carcinomas is published in Nature Genetics.

Dylan has been accepted into the ITMAT Certificate Program in Translational Science, and has also received a CTSA award, congrats!

Ben was profiled in an ASBMB “Research Spotlight”.

News in 2016

December 2016

Ben has been promoted to Professor of Biochemistry and Biophysics.

The Garcia Lab returns from a productive P01 Oncohistone grant team meeting at Rockefeller University, where Dylan and Ben presented the latest results.

The Garcia Lab says goodbye to Johayra, who will be moving onto her new position at Absorption Systems Panama, best of luck!

Collaborative work with the Kohli lab (Penn) on TET2 mutants that favor production of specific oxidized methylation products is published in Nature Chemical Biology, a study focused on understanding the cell-cycle control of CENP-A assembly in Molecular Cell, and our viewpoint on the proteomics field is published in the Journal of Cell Biology.

November 2016

Our collaborative study to investigate epigenetic modification patterns in a specific pediatric brain tumor (ependymomas) with the Venneti lab is published in Science Translational Medicine.

The Garcia Lab comes back from the annual Biochemistry and Molecular Biophysics Department Retreat. We had several posters from Ranran, Peder, Kelly, Mariel, Dylan, Sam, Kevin and Amber, and a talk by Ben.

Amber presented her research progress at the GCB Chalk Talks, nice job.

Lab method papers on enrichment of non-histone lysine methylated peptides by XJ, and combinatorial analysis of histone PTMs by Simone are published in Current Protocols in Protein Science, and Methods in Molecular Biology respectively, congrats.

October 2016

The Garcia Lab welcomes Visiting Professor Julia Pinheiro Chagas Da Cunha (Instituto Butantan, Brazil) for a 3 week stay in the lab.

Our lab’s collaborative studies are published in Molecular Cell. Simone’s work with the Bonasio Lab to map RNA-protein interaction domains, and an investigation with the Allis Lab (Rockefeller University) to understand cellular signaling and chromatin cross-talk during inflammatory stress response.

The Garcia Lab says goodbye to Yumiao, who will be moving to San Diego for the next phase of her career and life, congrats.

Peder presented a poster at the Microbiome Symposium here on campus, nice work.

The Garcia Lab was well represented at the SACNAS National Conference in Long Beach, CA. Mariel and Laura presented posters and Johayra gave a talk.

Lucy Chu has joined the lab as an undergraduate researcher, welcome!

Dylan has passed his 2nd year prelim exam, congrats!

Ben has been named to the Editorial Advisory Board for the Analytical Chemistry journal for a three year term.

September 2016

Mariel, Kelly, Peder, Ranran and Laura (Team MasSpectacular) completed a 10K run, great job!

Ben is elected to the Human Proteome Organization (HUPO) governing council (Western Region representative) for a three year term starting January 2017 to December 2019.

The Garcia Lab welcomes first-year BMB graduate student Mariel Mendoza to the group for the fall rotation.

The Garcia Lab welcomes Penn Biotechnology graduate student Dara Hawthorne to the lab for her fall independent study course.

August 2016

Mariel, Johayra and Laura have all been awarded travel fellowships to present their research work at the SACNAS National Conference in October. Congrats everyone!

The Garcia Lab had a fun time at the annual Summer Party. Congratulations to Johayra for taking the Gold Medal in the Bocce Ball Tournament, followed by Simone with the Silver, and Erica and Amber tying for Bronze.

Kelly’s comprehensive protocol paper on histone proteomics methods is published in Methods in Enzymology.

July 2016

Collaborative papers with the Adams Lab (University of Glasgow) and Eckenhoff Lab (Penn) are published in Genome Biology and the Journal of Biological Chemistry, respectively.

The Garcia Lab says goodbye to Visiting Professor Xiaolu Zhao who will be returning to Wuhan University.

Ben gives a talk and receives the Protein Science Young Investigator Award at the 30th Protein Society Symposium in Baltimore, MD.

The Garcia Lab comes backs from another great GRAAM (Garcia, Roeder, Allis, Armstrong, Muir) super chromatin group meeting at Rockefeller University. Johayra represented the lab by presenting her work on fatty-acyl histone modifications.

Kasia’s collaborative work with the Weitzman Lab (CHOP) on the role of protein VII in modulating chromatin structure during adenovirus infection is published in Nature, congrats!

June 2016

Two collaborative grants have been awarded funding. Our internal Penn ITMAT grant with Doug Wallace (CHOP) to study epigenetic effects of mitochondrial dysfunction, and an NIH R21 grant with Chris Pierce (Penn) to investigate cocaine addiction and the epigenome. Congrats all around!

Peder has been awarded a postdoctoral fellowship on the NCI-funded T32 Immunobiology of normal and neoplastic lymphocytes training grant. Congrats!

The Garcia Lab comes back from a fantastic ASMS Conference in San Antonio. We had poster presentations from Mariel, Johayra, Simone, Bhanu, Sam, Zuo-Fei, XJ, Kasia and Amber. Kelly and Ben also gave talks in the protein PTMs and stable isotope labeling sessions.

Simone’s work on quantification of phosphopeptide isomers using data independent acquisition MS is published in Molecular BioSystems, while Xiaoshi’s collaborative work with the Berger and Reinberg lab’s is published in Epigenetics and Chromatin, and Nature, respectively.

Dylan is awarded a Structural Biology and Molecular Biophysics training program graduate fellowship. Congrats!

The Garcia Lab welcomes incoming BMB graduate student Yekaterina Kori to the group for a summer rotation.

Ben speaks at Wallingford Elementary School about chemicals and how they affect our lives.

Amber has passed her 2nd year prelim exam, congratulations!

Mariel is awarded an NIH Research Supplement to promote diversity in health-related research to support her PhD studies, congrats!

Graduate student Laura Agosto (BMB) joins the lab (joint student with Kristen Lynch). Welcome to the group!

Amber has been awarded an Alex’s Lemonade Stand Foundation (ALSF) graduate fellowship in pediatric cancer research, congrats!

May 2016

Shu’s research on asymmetric phosphorylation of old histones is published in the Journal of Biological Chemistry, while Simone’s manuscript describing a newer multiplexing data independent acquisition method is accepted by the Proteomics journal.

Ben speaks to students at Strathhaven Middle School about the importance of scientific research for human health during the Dimensions in Living career day.

The Garcia Lab’s first major motion picture is finished starring Kelly, Bhanu and Simone. See our Journal of Visualized Experiments (JoVE) publication and video demonstrating our Bottom Up MS protocol for histone PTM analysis.

Mariel and Kevin have passed their 2nd year prelim exams, congratulations!

Our collaborative study to understand the effects of histone H3K36 mutations in sarcomas is published in Science.

The Garcia Lab says goodbye to Tara who has finished her undergraduate studies at Penn and will be off to graduate school at Columbia University, congrats!

Collaborative studies with the Witze lab (Penn) and Dou lab (Michigan) are published in Molecular Cell. These studies feature experiments performed by Garcia Lab members Bhanu, Xing-Jun and Qi.

Mariel has been awarded a Delaware Valley Mass Spectrometry Discussion Group travel award to present her poster at the upcoming 64th American Society for Mass Spectrometry Conference. Congratulations!

Edwin has been awarded an NIH NRSA F31 Graduate Fellowship, congrats!

Simone has been awarded a New Jersey Section American Chemical Society Mass Spectrometry Discussion Group travel award to present his poster at the 64th American Society for Mass Spectrometry Conference. Congrats!

April 2016

Xiaoshi’s paper on GlcNAc dynamics is accepted by Molecular and Cellular Proteomics.

The Garcia lab says goodbye to Dr. Xiaoshi Wang who will be starting the next phase of her career at Novavax, congratulations!

The Garcia Lab comes backs from a productive GRAAM (Garcia, Roeder, Allis, Armstrong, Muir) super chromatin group meeting at Princeton University. Yumiao represented the lab by presenting her work on cellular signaling into chromatin.

Dr. Ranran Wu joins the Garcia Lab as a Postdoctoral Scientist, welcome!

March 2016

The new Penn SOM Quantitative Proteomics Core is officially open. Dr. Xing-Jun Cao will oversee the core as the Technical Director, and Dr. Rong Meng has started as a Research Specialist.

Anna’s paper combining click chemistry and mass spectrometry to investigate newly synthesized histones is now published in ACS Chemical Biology.

The Garcia Lab attends the US HUPO Conference in Boston. We had featured talks by Simone and Kelly, and “lightning” talks by Sam and Kasia. Zuo-Fei, Sam, Kasia and Bhanu also presented posters, and Ben led an evening workshop. All in all, it was a fantastic combination of great science and a good time.

John has been awarded a K12 Paul Calabresi Career Development Award for Clinical Oncology, congratulations!

Graduate student Dylan Marchione (PGG) joins the Garcia Lab, welcome!

The special issue of Molecular and Cellular Proteomics (MCP) focused on Chromatin Biology and Epigenetics where Ben was a special guest editor is now published! Check out the special cover image artwork commissioned for this issue which had significant input from Ben and Simone.

Yumiao’s chemical proteomics approach to map signaling pathway interactions with chromatin is published in Molecular and Cellular Proteomics.

Collaborative studies to understand global lysine methylation and intact histone proteoforms are published in Molecular and Cellular Proteomics. These publications feature research by Kelly, Mariel, Simone and Xing-Jun, congrats.

February 2016

Team Oncohistone (Congcong, Johayra, Bhanu, Simone and Zuo-Fei) had a productive kickoff meeting with the other NIH P01 grant team labs (Dave Allis, Tom Muir, Peter Lewis and Nada Jabado labs) up at Rockefeller University. Progress on understanding the epigenetic aspects of childhood brain and other cancers will be updated at http://www.oncohistone.org/.

The Garcia lab presents in the Biochemistry and Molecular Biophysics Department Friday research discussion. Marial and Yumiao presented their latest results from their studies, nice job!

Ben Garcia has won the 2016 Young Investigator Award from The Protein Society. Read the Penn press release here.

New Postdoctoral researcher Peder Lund joins the Garcia lab.

Michelle’s work on the role of histone H4 acetylation and their reader Brd4 in embryonic stems cells is published in BMC Genomics.

Visiting Professor Dr. Xiaolu Zhao arrives in the lab, welcome!

Bhanu’s research on identifying epigenetic signatures during stem cell renewal and differentiation is published in Proteomics.

January 2016

The Garcia lab welcomes rotation students Keith Campagno and Ziyang Xu to the lab.

We welcome our new postdoc Dr. Yanping Lin to the lab.

News in 2015

December 2015

The Garcia Lab had their annual Holiday Party. There was lots of good food, a gift exchange, Kelly won the Wii Just Dance tournament, and we also said goodbye to Shu who will be leaving for her new position at Dartmouth University, congrats!

Ben Garcia attends the Enabling Technologies Proteomics (ETP) Symposium held in Lake Louise, Canada, where he gives an invited talk and also receives the ETP Ken Standing Award.

The Garcia lab says goodbye to Dr. Shu Lin who has accepted a Scientist position at Dartmouth University, Congrats!

November 2015

Genome Web publishes a story on our methodology to link cellular signaling to chromatin mediated gene expression.

The Garcia Lab attends the Biochemistry and Biophysics departmental retreat at the Skytop Lodge in the Pocono Mountains. Simone gave a nice talk, and Kelly won the First Place Kate Ferguson Award in Biochemistry for her poster presentation, congrats!

Qi Guo joins the lab as a Technician, welcome!

Ben Garcia gives an invited talk at the Canadian Cancer Research Conference in Montreal, Canada.

September 2015

Ben gives an invited talk at the World HUPO Congress in Vancouver, BC, Canada.

Visiting graduate student Catarina Charneira (Instituto Superior Técnico, Portugal) joins the lab.

Undergraduate Tara Lorimer joins the lab for her senior thesis work, welcome!

The Garcia lab welcomes rotation students Laura Agosto and Hannah Richter to the lab.

August 2015

The Garcia lab signs a Technology Alliance Partnership with Thermo Scientific to keep Penn at the forefront of cutting-edge proteomics research.

Ben gives an invited talk at the American Chemical Society National meeting in Boston, MA.

The Garcia lab’s Histone Code research is discussed in Accelerating Proteomics: http://acceleratingscience.com/proteomics/bottom-up-middle-down-any-which-way-to-characterize-histone-ptms/

Congcong Lu joins the lab as a Postdoctoral researcher, welcome!

Ben Garcia is named the ETP Ken Standing Award winner.

July 2015

Graduate students Mariel Coradin (BMB) and Kevin Janssen (BMB) join the lab, welcome!

Ben is awarded the Leukemia and Lymphoma Society Dr. Robert Arceci Scholar Award.

Visiting graduate student Nanika Coetzee (University of Pretoria, South Africa) joins the lab for summer research.

Undergraduate Kella Tran-Du joins the lab for summer research, welcome aboard.

June 2015

The lab returns from a successful showing at the American Society for Mass Spectrometry conference in Denver, CO. We had several posters and talks by Simone and Sam.

Ben Garcia becomes a permanent member of the Enabling Bioanalytical and Imaging Technologies (EBIT) NIH study section (2015-2021)

Kelly Karch wins a New Jersey Section American Chemical Society Mass Spectrometry Discussion Group travel award to present her poster at the American Society for Mass Spectrometry Conference.

Ben Garcia is elected Secretary of the Delaware Valley Mass Spectrometry Discussion Group.

Sam Wein wins a Delaware Valley Mass Spectrometry Discussion Group travel award to present his poster at the American Society for Mass Spectrometry Conference.

May 2015

Graduate student Amber Weiner (GCB) joins the lab, welcome!

March 2015

Ben gives an invited talk at the PITTCON conference in New Orleans, LA.

Ben Garcia gives an invited talk at the US HUPO conference in Tempe, AZ.

February 2015

The Garcia Lab is featured in the Biochemistry and Molecular Biophysics Department video describing the research performed across the department.

Anna Arnaudo successfully defends her PhD dissertation, congrats!

The Garcia Lab is interviewed about their work on using data-independent approaches for histone modification analysis (https://www.genomeweb.com/proteomics-protein-research/upenn-team-investigating-dia-mass-spec-tool-study-histone-ptms).

Johayra Simithy joins the lab as a Postdoctoral researcher.

January 2015

Michelle Gonzales-Cope successfully defends her PhD dissertation, congrats!

Kelly Karch is awarded a Chemistry Biology Interface Training Program graduate fellowship. Congrats!

News in 2014

December 2014

Laura-Mae Britton successfully defends her PhD dissertation and is off to her position as an Assistant Medical Director at MedEdNow, LLC.

November 2014

Shu Lin gives a talk at the Biochemistry and Molecular Biophysics Departmental Retreat.

October 2014

Kasia Kulej joins the lab as a Postdoctoral researcher.

Ben Garcia is invited to present at the ThermoFisher Scientific Mass Spectrometry User Meetings in Somset, NJ and Boston, MA.

August 2014

Ben is invited to give a talk at the 11th International Symposium on Mass Spectrometry in the Health and Life Sciences, San Francisco CA.

Ozlem Onder joins the lab as a scientist for a collaborative project with Martin Carroll’s lab.

Ben is awarded the American Chemical Society Arthur F. Findeis Award for Achievements by a Young Analytical Scientist.

Ben gives an invited talk at the American Chemical Society National meeting in San Francisco, CA.

Rosie Molden successfully defends her PhD dissertation, and is off to her position at Regeneron, congrats!

July 2014

Undergraduate Bhavna Jois joins the lab for summer research, welcome aboard.

June 2014

The lab returns from a successful showing at the American Society for Mass Spectrometry conference in Baltimore, MD. We had several posters and talks by Shu and Simone.

Kelly Karch wins a Delaware Valley Mass Spectrometry Discussion Group travel award to present her poster at the American Society for Mass Spectrometry Conference.

Ben Garcia is awarded the AB Sciex Young Investigator Award

Anna Arnaudo wins a New Jersey Section American Chemical Society Mass Spectrometry Discussion Group travel award to present her poster at the American Society for Mass Spectrometry Conference.

May 2014

Kelly Karch and Sam Wein pass their prelim exams, congrats!

March 2014

Ben Garcia is awarded the Pittsburg Conference (Pittcon) Achievement Award

Ben gives an invited talk at the PITTCON conference in Chicago, IL.

Simone Sidoli joins the lab as a Postdoctoral researcher.

Ben Garcia gives an invited talk at the US HUPO conference in Seattle, WA.

The Garcia Lab is featured in a video describing research in the Biochemistry and Biophysics Department at Penn (https://www.youtube.com/watch?v=VJ1l3N8a_7M).